File:Optogenetic-Control-of-Targeted-Peripheral-Axons-in-Freely-Moving-Animals-pone.0072691.s006.ogv
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DescriptionOptogenetic-Control-of-Targeted-Peripheral-Axons-in-Freely-Moving-Animals-pone.0072691.s006.ogv |
English: Experimental setup for treadmill experiment. AAV6:ChR2 was injected into the tibialis anterior or gastrocnemius, and four to six weeks later, an optical nerve cuff was implanted around the sciatic nerve. Surface EMG electrodes were also implanted on the targeted muscle and the non-injected contralateral muscle on the opposite leg. Rats were trained to use the treadmill, and 3 days following cuff/EMG implantation, light was applied during walking on the treadmill. Muscle twitches are not observable in the video (due to gross limb movements, see instead Movie S2), however, the EMG data demonstrates distinct optogenetic activation of the targeted muscle (Figure 4B). |
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Source | Movie S3 from Towne C, Montgomery K, Iyer S, Deisseroth K, Delp S (2013). "Optogenetic Control of Targeted Peripheral Axons in Freely Moving Animals". PLOS ONE. DOI:10.1371/journal.pone.0072691. PMID 23991144. PMC: 3749160. | ||
Author | Towne C, Montgomery K, Iyer S, Deisseroth K, Delp S | ||
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current | 21:28, 4 September 2013 | 15 s, 960 × 540 (1.43 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Towne C, Montgomery K, Iyer S, Deisseroth K, Delp S |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | Experimental setup for treadmill experiment. AAV6:ChR2 was injected into the tibialis anterior or gastrocnemius, and four to six weeks later, an optical nerve cuff was implanted around the sciatic nerve. Surface EMG electrodes were also implanted on the targeted muscle and the non-injected contralateral muscle on the opposite leg. Rats were trained to use the treadmill, and 3 days following cuff/EMG implantation, light was applied during walking on the treadmill. Muscle twitches are not observable in the video (due to gross limb movements, see instead Movie S2), however, the EMG data demonstrates distinct optogenetic activation of the targeted muscle (Figure 4B). |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2013 |