File:High-quality-genome-(re)assembly-using-chromosomal-contact-data-ncomms6695-s2.ogv

English: Supplementary Movie 1 Iterative reassembly of Trichoderma reesei genome using genomic contact data, showing the selected genome structure on the right and the corresponding contact matrix on the left. The contigs and scaffolds of the genome structure on the right panel are ordered according to their size along the vertical axis, with the longest scaffolds positioned at the top and the smallest ones at the bottom. During the first part of the movie, the original assembly of 76 scaffolds is binned into 1200 elements. The assembly process has not started yet. Once this binning is complete, new genome structures are iteratively tested, one bin at a time (Figure 1F). Arrays of syntenic bins are indicated along the horizontal axis on the right, with the same color code as in the original assembly. At first, very small scaffolds encompassing only a few bins appear, that grow progressively longer. The likelihood and the number of scaffolds of the current structure are indicated in the left panel. When the iterative process stops, the ongoing structure presents 7 large scaffolds covering 99.8% of the original set of 76 scaffolds, and 4 small bins. If allowed to run longer, the algorithm would keep fine-tuning the genome structure by looking for small improvements in the likelihood.