File:Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails to Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection.pdf
Jump to navigation
Jump to search
Size of this JPG preview of this PDF file: 448 × 600 pixels. Other resolutions: 179 × 240 pixels | 358 × 480 pixels | 573 × 768 pixels | 1,218 × 1,631 pixels.
Original file (1,218 × 1,631 pixels, file size: 1.98 MB, MIME type: application/pdf, 14 pages)
Captions
Captions
Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails to Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection
Summary[edit]
| Description |
English: Widespread antibiotic use in clinical medicine and the livestock industryhas contributed to the global spread of multidrug-resistant (MDR) bacterial patho-gens, including Acinetobacter baumannii. We report on a method used to produce apersonalized bacteriophage-based therapeutic treatment for a 68-year-old diabeticpatient with necrotizing pancreatitis complicated by an MDR A. baumannii infection.Despite multiple antibiotic courses and efforts at percutaneous drainage of a pancre-atic pseudocyst, the patient deteriorated over a 4-month period. In the absence ofeffective antibiotics, two laboratories identified nine different bacteriophages withlytic activity for an A. baumannii isolate from the patient. Administration of thesebacteriophages intravenously and percutaneously into the abscess cavities was asso-ciated with reversal of the patient’s downward clinical trajectory, clearance of theA.baumanniiinfection, and a return to health. The outcome of this case suggests thatthe methods described here for the production of bacteriophage therapeutics couldbe applied to similar cases and that more concerted efforts to investigate the use oftherapeutic bacteriophages for MDR bacterial infections are warranted. |
| Date | |
| Source | https://journals.asm.org/doi/10.1128/AAC.00954-17 |
| Author | Robert T. Schooley, Biswajit Biswas, Jason J. Gill, Adriana Hernandez-Morales, Jacob Lancaster, Lauren Lessor, Jeremy J. Barr, SHOW ALL (34 AUTHORS), Sharon L. Reed, Forest Rohwer, Sean Benler, Anca M. Segall, Randy Taplitz, Davey M. Smith, Kim Kerr, Monika Kumaraswamy, Victor Nizet, Leo Lin, Melanie D. McCauley, Steffanie A. Strathdee, Constance A. Benson, Robert K. Pope, Brian M. Leroux, Andrew C. Picel, Alfred J. Mateczun, Katherine E. Cilwa, James M. Regeimbal, Luis A. Estrella, David M. Wolfe, Matthew S. Henry, Javier Quinones, Scott Salka, Kimberly A. Bishop-Lilly, Ry Young, Theron Hamilton |
Licensing[edit]
|
This work is in the public domain in the United States because it is a work prepared by an officer or employee of the United States Government as part of that person’s official duties under the terms of Title 17, Chapter 1, Section 105 of the US Code.
Note: This only applies to original works of the Federal Government and not to the work of any individual U.S. state, territory, commonwealth, county, municipality, or any other subdivision. This template also does not apply to postage stamp designs published by the United States Postal Service since 1978. (See § 313.6(C)(1) of Compendium of U.S. Copyright Office Practices). It also does not apply to certain US coins; see The US Mint Terms of Use.
|
 |
| This file has been identified as being free of known restrictions under copyright law, including all related and neighboring rights. | ||
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 00:40, 10 July 2022 |  | 1,218 × 1,631, 14 pages (1.98 MB) | Koavf (talk | contribs) | Uploaded a work by Robert T. Schooley, Biswajit Biswas, Jason J. Gill, Adriana Hernandez-Morales, Jacob Lancaster, Lauren Lessor, Jeremy J. Barr, SHOW ALL (34 AUTHORS), Sharon L. Reed, Forest Rohwer, Sean Benler, Anca M. Segall, Randy Taplitz, Davey M. Smith, Kim Kerr, Monika Kumaraswamy, Victor Nizet, Leo Lin, Melanie D. McCauley, Steffanie A. Strathdee, Constance A. Benson, Robert K. Pope, Brian M. Leroux, Andrew C. Picel, Alfred J. Mateczun, Katherine E. Cilwa, James M. Regeimbal, Luis A.... |
You cannot overwrite this file.
File usage on Commons
The following page uses this file: