File:CRISPR CAS9 technology in biomedicine.tif

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Captions

Captions

Cas9 in complex with single guide RNA and target DNA

Summary[edit]

Description
English: Cas9 in complex with single guide RNA is used as a molecular tool for gene therapy. SpCas9 endonuclease uses the single guide RNA to find a specific target sequence to introduce double-strand break. Then, the cell introduces a mutation at the site of the break through the repair mechanisms of damaged DNA.
Русский: Cas9 в комплексе с направляющей РНК используется в качестве молекулярного инструмента для генной терапии. Эндонуклеаза SpCas9 с помощью направляющей РНК находит точное место в геноме, чтобы внести двухцепочечный разрыв. Затем клетка вносит мутацию в месте внесенного разрыва с помощью механизмов репарации поврежденной ДНК.
English: CRISPR/Cas9 genome editing technology. Three-dimensional structure of spCas9 ID 5Y36 from the Protein Data Bank (PDB) database. Structural image was prepared with the PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC and Adobe Illustrator.
Date
Source Own work
Author Elena I Leonova

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current21:13, 28 March 2020Thumbnail for version as of 21:13, 28 March 20207,536 × 6,228 (210.74 MB)Elena I Leonova (talk | contribs)Uploaded own work with UploadWizard

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