File:CRISPR-Cas9 gene editing and how it works - with Jennifer Doudna.webm
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Jennifer Doudna, biochemist at UC Berkeley, explains how CRISPR-Cas9 works
Summary[edit]
| Description |
English: What is CRISPR-Cas9 and how does it work? How do we edit genes? Jennifer Doudna, biochemist at UC Berkeley, explains.
The gene editing technique, created by UC Berkeley biochemist Jennifer Doudna and her colleague, Emmanuelle Charpentier, director of the Max Planck Institute of Infection Biology in Berlin, has taken the research and clinical communities by storm as an easy and cheap way to make precise changes in DNA in order to disable genes, correct genetic disorders or insert mutated genes into animals to create models of human disease. CRISPR-Cas9 is a hybrid of protein and RNA – the cousin to DNA – that functions as an efficient search-and-snip system in bacteria. It arose as a way to recognize and kill viruses, but Doudna and Charpentier realized that it could also work well in other cells, including humans, to facilitate genome editing. The Cas9 protein, obtained from the bacteria Streptococcus pyogenes, functions together with a “guide” RNA that targets a complementary 20-nucleotide stretch of DNA. Once the RNA identifies a sequence matching these nucleotides, Cas9 cuts the double-stranded DNA helix. |
| Date | |
| Source | https://www.youtube.com/watch?v=avM1Yg5oEu0 |
| Author | Roxanne Makasdjian and Stephen McNally for the University of California, Berkeley |
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Cas9 Apo Structure.png (by Ben.lafrance).Licensing[edit]
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- Cas9 Apo Structure image
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 01:06, 13 October 2021 | 2 min 21 s, 1,920 × 1,080 (31.74 MB) | Mysterymanblue (talk | contribs) | Uploaded a work by Roxanne Makasdjian and Stephen McNally for the [https://www.youtube.com/channel/UCZAXKyvvIV4uU4YvP5dmrmA University of California, Berkeley] from https://www.youtube.com/watch?v=avM1Yg5oEu0 with UploadWizard |
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