File:Schematic overview view of niche components..jpg

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English: Stem cell fate decisions are mediated by interactions with the matrix proteins, soluble factors and other cell types in stem cell niches. In particular, this chapter focuses on mechanisms by which niche components direct stem cell fate decisions, including (1) and (2) immobilization of signals to control activity and dosage, (3) direct interactions with ECM proteins, (4) complex signaling feedback from adjacent niche cells, and presentation of mechanical cues. SC=stem cell; NC=niche cell; GF=growth factor; DC=differentiated cell.
Date Published September 11, 2008.
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StemBook Figure 1 Schematic overview view of niche components.

  • Eshghi, S. and Schaffer, D.V., Engineering microenvironments to control stem cell fate and function (September 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.5.1, http://www.stembook.org.
Author Eshghi, S. and Schaffer, D.V., Engineering microenvironments to control stem cell fate and function (September 15, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.5.1, http://www.stembook.org.
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