File:Mouse embryo Intravascular trafficking is independent of MYB and CX3CR1.jpg
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| Description | Fig 4. Intravascular trafficking is independent of MYB and CX3CR1. a Schematic graph of the Cx3cr1GFP/+ Myb−/− mouse model. b Bright field images of isolated embryos at E16.5 indicating the absence of fetal definitive hematopoiesis (i.e. severe anemia). c, d Visualization (c) and quantification (d) of CX3CR1+ cells in the YS of Myb+/+ or Myb−/− mice at indicated time points; all comparisons of Myb+/+ vs. Myb−/− are n.s. (two-tailed t-test: E9.5 p = 0.9818, E10.5 p = 0.8894, E12.5 p = 0.6900, E16.5 p = 0.9543); mean ± standard deviation (SD, error bars). e Quantification of intravascular CX3CR1+ cells in a Myb+/+ and Myb−/− YS on indicated time points; E10.5: n.s. (two-tailed Mann–Whitney: E10.5 p = 0.4537); median ± IQR. f Quantification of CX3CR1+ cell densities per microscopic field of 400 × 400 µm in embryonic tissues at E10.5; *** p < 0.001 (two-tailed t-test); mean ± SD. g Quantification of intravascular CX3CR1+ cells in YS of Cx3cr1GFP/+ and Cx3cr1GFP/GFP E10.5 embryos; n.s. (two-tailed t-test: p = 0.6065); mean ± SD. Scale bar is 100 µm (c) |
| Date | |
| Source | https://www.nature.com/articles/s41467-017-02492-2/figures/4 Yolk sac macrophage progenitors traffic to the embryo during defined stages of development. Nat Commun 9, 75 (2018). https://doi.org/10.1038/s41467-017-02492-2 |
| Author | Stremmel, C., Schuchert, R., Wagner, F. et al. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 20:48, 21 April 2024 | | 1,360 × 2,512 (1.84 MB) | Rasbak (talk | contribs) | {{Information |description=Fig 4. Intravascular trafficking is independent of MYB and CX<sub>3</sub>CR1. a Schematic graph of the Cx<sub>3</sub>cr1<sup>GFP/+</sup> Myb<sup>−/−</sup> mouse model. b Bright field images of isolated embryos at E16.5 indicating the absence of fetal definitive hematopoiesis (i.e. severe anemia). c, d Visualization (c) and quantification (d) of CX<sup>3</sup>CR1+ cells in the YS of Myb<sup>+/+</sup> or Myb<sup>−/−</sup> mice at indicated time points; all comparisons... |
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