File:Molecular-and-Cellular-Basis-of-Microvascular-Perfusion-Deficits-Induced-by-Clostridium-perfringens-ppat.1000045.s003.ogv
Molecular-and-Cellular-Basis-of-Microvascular-Perfusion-Deficits-Induced-by-Clostridium-perfringens-ppat.1000045.s003.ogv (Ogg Theora video file, length 9.0 s, 320 × 240 pixels, 2.35 Mbps, file size: 2.52 MB)
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DescriptionMolecular-and-Cellular-Basis-of-Microvascular-Perfusion-Deficits-Induced-by-Clostridium-perfringens-ppat.1000045.s003.ogv |
English: Video showing effect of superfusion with supernatants from an α-toxin/perfringolysin O mutant (JIR4444) of C. perfringens. Several areas of muscle are shown shortly after intravenous administration of sodium fluorescein. After 60 min of superfusion, substantial capillary perfusion is apparent in these tissues (demonstrated by the presence of intravenous fluorescein). Indeed, the degree of capillary perfusion in muscles exposed to supernatant deficient in α-toxin and perfringolysin O is comparable to that in tissues exposed to TPG (Video S1), indicating the combined actions of these toxins in promoting loss of perfusion. |
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Source | Video S3 from Hickey M, Kwan R, Awad M, Kennedy C, Young L, Hall P, Cordner L, Lyras D, Emmins J, Rood J (2008). "Molecular and Cellular Basis of Microvascular Perfusion Deficits Induced by Clostridium perfringens and Clostridium septicum". PLOS Pathogens. DOI:10.1371/journal.ppat.1000045. PMID 18404211. PMC: 2275794. | ||
Author | Hickey M, Kwan R, Awad M, Kennedy C, Young L, Hall P, Cordner L, Lyras D, Emmins J, Rood J | ||
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 11:58, 17 November 2012 | 9.0 s, 320 × 240 (2.52 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Hickey M, Kwan R, Awad M, Kennedy C, Young L, Hall P, Cordner L, Lyras D, Emmins J, Rood J |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | Video showing effect of superfusion with supernatants from an ?-toxin/perfringolysin O mutant (JIR4444) of C. perfringens. Several areas of muscle are shown shortly after intravenous administration of sodium fluorescein. After 60 min of superfusion, substantial capillary perfusion is apparent in these tissues (demonstrated by the presence of intravenous fluorescein). Indeed, the degree of capillary perfusion in muscles exposed to supernatant deficient in ?-toxin and perfringolysin O is comparable to that in tissues exposed to TPG (Video S1), indicating the combined actions of these toxins in promoting loss of perfusion. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2008-04 |
Structured data
Items portrayed in this file
depicts
- Immune response
- Innate immunity
- Videos of infectious diseases and disorders
- Bacterial toxins
- Calcium-binding proteins
- Cell death
- Clostridium perfringens
- Clostridium septicum
- Gas gangrene
- Fungal gene expression regulation
- Hemolysin proteins
- Inbred BALB C mice
- Microcirculation
- Video microscopy
- Skeletal muscle
- Insertion (genetics)
- Regional blood flow
- Phospholipase C