File:Glutamate-Bound-NMDARs-Arising-from-In-Vivo-like-Network-Activity-Extend-Spatio-temporal-pcbi.1003590.s009.ogv

English: Movie 1 shows the membrane voltage in the Layer 5 Pyramidal cell model during nearly synchronous stimulus evoked synaptic stimulation with 30 synapses on a terminal dendritic branch (each synapse firing at 200 Hz from 100–105 ms). The voltage response to the synaptic input is shown under 3 conditions: 1) Control with no background activity. 2) With background activity from 1500 excitatory synapses firing randomly at 0.85 Hz. 3) With balanced background synaptic input including inhibition from SOM-like (GABAA) and NGF-like (GABAA and GABAB) mediated inhibition. While the spread of depolarisation in the control case is limited to the stimulated branch and its near neighbours, the excitatory background input causes regenerative depolarisation in branches further away. The spread of depolarisation is also widespread for balanced background synaptic input, but the presence of inhibition shortens the duration compared with background excitation alone.