File:Cell-movement-pbio.1001256.s009.ogv

English: Simulations of AVE migration in the presence and absence of rosettes. Simulations were run with a large threshold distance at which vertices join (allowing rosettes to form—at left) and with a very small threshold distance at which vertices join (preventing many rosettes from forming—at right). All other parameters were kept exactly the same. For simulations in which rosettes can easily form, AVE cells migrate as a group in a manner very similar to that observed in cultured embryos. In simulations with reduced rosette formation, AVE cells migrate in an abnormal manner, splitting into separate groups that spread more broadly than normally observed.