File:An increase of Reelin-positive cells changes morphology of migrating neurons - journal.pone.0001454.g007.jpg

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English: Increase of Reelin-positive cells changes morphology of migrating neurons
  • A) + B): Changes in radial fiber projection patterns in E10 telencephali by Dbx1 misexpression.

Compared with control (A), straight projection of radial fibers is evident in the Dbx1-misexpressed pallium (arrows in B).

  • C) to E): Morphological changes in migrating neurons by Dbx1-misexpression.

In control, GFP-labeled migrating neurons extend many short processes (arrowheads in C). In contrast, In Dbx1-misexpressed pallium, migrating neurons display a bipolar shape (D), and attached to the radial fibers (arrowheads in E). Each radial fiber extends to the Reelin-positive cells localized at the pial surface (an arrow in F).

Scale bars, 50 µm (B), 20 µm (D), 10 µm (F, G)
Date 16 January 2008 (PLoS publishing date)
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From: Nomura T, Takahashi M, Hara Y, Osumi N. Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex. PLoS ONE. 2008 Jan 16;3(1):e1454. PMID 18197264 doi: 10.1371/journal.pone.0001454

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2175532&rendertype=figure&id=pone-0001454-g007
Author Nomura T et al.
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