File:Ten daily doses of ethanol exposure reduced neurogenesis in hippocampal dentate gyrus during combined ethanol and LPS treatments.jpg
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Size of this preview: 454 × 600 pixels. Other resolutions: 182 × 240 pixels | 363 × 480 pixels | 581 × 768 pixels | 1,200 × 1,585 pixels.
Original file (1,200 × 1,585 pixels, file size: 372 KB, MIME type: image/jpeg)
File information
Structured data
Captions
DescriptionTen daily doses of ethanol exposure reduced neurogenesis in hippocampal dentate gyrus during combined ethanol and LPS treatments.jpg |
English: Figure 6. Ten daily doses of ethanol exposure reduced neurogenesis in hippocampal dentate gyrus during combined ethanol and LPS treatments. Male C57BL/6J mice were treated intragastrically with ethanol (5 g/kg, i.g.) for either 1 day or 10 days and injected intraperitoneally (i.p.) with LPS (3 mg/kg, i.p.) 24 hrs after ethanol treatment. Mice were sacrificed 1 hr following saline or LPS administration. Brain sections were fixed and stained with anti-mouse PCNA (a marker for proliferation of neural progenitor cells) and anti-goat doublecortin (a marker for immature or newly born neurons) antibodies. (A) Ethanol (5 g/kg, i.g., 1 day) pre-treated group, LPS did not show a decrease in the number of PCNA and doublecortin-IR cells. (B) Ethanol (5 g/kg, i.g., 10 days) pre-treated mice, LPS significantly decreased PCNA and doublecortin-IR cells, suggesting that 10 daily doses of ethanol inhibits neurogenesis during combined ethanol and LPS treatments. (C) The pictures represent PCNA-IR cells in control (upper panel) and ETOH-LPS treated (lower panel) dentate gyri of the hippocampus. (D) Representative pictures of doublecortin (DCX) immunoreactivity. DCX expression was shown in control brain (upper panel) and ETOH-LPS treated brain (lower panel). |
Date | |
Source | Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment |
Author | Qin L, He J, Hanes RN, Pluzarev O, Hong JS, Crews FT. |
Permission (Reusing this file) |
© 2008 Qin et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
This file is licensed under the Creative Commons Attribution 2.0 Generic license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 09:11, 30 August 2009 | 1,200 × 1,585 (372 KB) | CopperKettle (talk | contribs) | {{Information |Description={{en|1=Figure 6. Ten daily doses of ethanol exposure reduced neurogenesis in hippocampal dentate gyrus during combined ethanol and LPS treatments. Male C57BL/6J mice were treated intragastrically with ethanol (5 g/kg, i.g.) for |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
_error | 0 |
---|