File:Repro4 mutation in Spermatocytes.jpg
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Repro4_mutation_in_Spermatocytes.jpg (700 × 362 pixels, file size: 111 KB, MIME type: image/jpeg)
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DescriptionRepro4 mutation in Spermatocytes.jpg |
English: Wild-type spermatocyte progression compared to repro4 mutated spermatocytes. |
Date | |
Source | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909985/ |
Author | Fengyun Sun, Mary Ann Handel |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 02:26, 23 April 2014 | 700 × 362 (111 KB) | Amanaresi (talk | contribs) | User created page with UploadWizard |
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Author | Fengyun Sun and Mary Ann Handel * |
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JPEG file comment | In spite of evolutionary conservation of meiosis, many of the genes that control mammalian meiosis are still unknown. We report here that the ENU-induced repro4 mutation, identified in a screen to uncover genes that control mouse meiosis, causes failure of spermatocytes to exit meiotic prophase I via the G2/MI transition. Major events of meiotic prophase I occurred normally in affected spermatocytes and known regulators of the meiotic G2/MI transition were present and functional. Deep sequencing of mutant DNA revealed a mutation located in an intron of the Mtap2 gene, encoding |
Date and time of digitizing | 14:52, 10 January 2011 |
Software used | Microsoft® Office Word 2007 |
File change date and time | 21:07, 2 October 2012 |
Date metadata was last modified | 21:07, 2 October 2012 |
Keywords | meiosis; spermatogenesis; microtubule-associated protein |
Unique ID of original document | uuid:8cef5a49-6d67-4bfe-a276-60ba1c0978bf |
Copyright status | Copyright status not set |
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