File:Inborn errors of metabolism of phenylalanine and tyrosine.svg

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Captions

Captions

Phenylalanine/tyrosine catabolic pathway overlaid with associated pathologies.

Summary[edit]

Description
English: Errors of Metabolism:

PKU—phenylketonuria,
HT-2—tyrosinemia type II,
HT-3—tyrosinemia type III,
AKU—alkaptonuria,
HT-1—tyrosinemia type I.

Substrates/products:
Phe—phenylalanine,
Tyr—tyrosine,
pHPP—p-hydroxyphenylpyruvate,
hga—homogentisate,
maa—maleylacetoacetate,
faa—fumarylacetoacetate.

Enzymes:
PAH—phenylalanine hydroxylase,
TAT—tyrosine transaminase,
HPD—4-hydroxyphenylpyruvate dioxygenase,
HGD—homogentisate oxidase,
MAAI—maleylacetoacetate isomerase,
FAH—fumarylacetoacetase.

Cofactors:
O
2
—molecular oxygen,
4a-OH-BH
4
—4a-hydroxytetrahydrobiopterin,
H
2
O
—water,
q-BH
2
—7,8-dihydrobiopterin,
NADH/NAD+
—nicotinamide adenine dinucleotide,
BH
4
—tetrahydrobiopterin,
α-KG—alpha-ketoglutarate,
Glu—glutamate,
CO
2
—carbon dioxide,

H+
—proton.
Date
Source Own work
Author Bradford Morris

Licensing[edit]

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w:en:Creative Commons
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File history

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Date/TimeThumbnailDimensionsUserComment
current12:18, 13 May 2019Thumbnail for version as of 12:18, 13 May 2019633 × 375 (106 KB)Bradford Morris (talk | contribs)Minor aesthetic changes.
21:46, 12 May 2019Thumbnail for version as of 21:46, 12 May 2019629 × 374 (139 KB)Bradford Morris (talk | contribs)Text moved when resized.
21:09, 12 May 2019Thumbnail for version as of 21:09, 12 May 2019671 × 399 (74 KB)Bradford Morris (talk | contribs)User created page with UploadWizard

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