File:Active site RNA replicase.png

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Captions

Captions

Schematic presentation of the RdRp (RNA replicase) active site

Summary[edit]

Description
English: Schematic presentation of the RdRp active site. The aspartates (Asp) of yellow and orange bind divalent metal ions (marked Mg and shaded grey), which are used to coordinate the formation of a new phosphodiester bond at the 3′-OH (red in panel ii) of the nascent strand (yellow). The general acid (red Lys/His in panel ii) is positioned near the β-phosphate of the incoming NTP to protonate the PPi leaving group.
Nederlands: Schematische weergave van de actieve plaats in RNA replicase ofwel RdRp. De aspartaten (Asp geel en oranje) binden tweewaardige metaalionen (magnesium; Mg), die worden gebruikt om de vorming van een nieuwe fosfodiesterbinding aan 3′-OH (rood in paneel ii) van de groeiende streng (geel) te coördineren. Het algemene zuur (Lys/His rood in paneel ii) is gepositioneerd nabij het β-fosfaat van het binnenkomende NTP om de vertrekkende PPi-groep te protoneren.
Date
Source te Velthuis, A.J.W. Common and unique features of viral RNA-dependent polymerases. Cell. Mol. Life Sci. 71, 4403–4420 (2014). https://doi.org/10.1007/s00018-014-1695-z
Author A.J.W te Veldhuis

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