File:Activation mechanisms of CAR.png

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English: Inactivated CAR is retained in the cytosol. Upon binding of TCPOBOP, CAR gets dephosphorylated by PP2A and translocates into the nucleus. Here, it forms a complex with RXR and binds to the PB-responsive enhancer module. Another possibility to activate CAR is the indirect activation through PB. PB binds competitively to EGFR, thus inducing the dephosphorylation of RACK-1. RACK-1 then stimulates PP2A to dephosphorylate CAR, which is then translocated into the nucleus.
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Author LisaMausi123

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current14:14, 19 December 2014Thumbnail for version as of 14:14, 19 December 20147,271 × 4,588 (739 KB)LisaMausi123 (talk | contribs)User created page with UploadWizard

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