File:41598 2018 29560 Fig1 HTML.png

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Organization of arterivirus genomes.

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Description
English: Organization of arterivirus genomes. Arterivirus open reading frames (ORFs) are drawn to scale. ORFs 1a and 1b can be joined through a −1 programmed ribosomal frameshift to express polyprotein 1a,b. Nonstructural protein 2 transframe fusion product (nsp2TF) is produced through a −2 programmed ribosomal frameshift by most, but not all, arteriviruses. The plot at the bottom of the figure shows the predicted organization of this TF as a transmembrane domain in the case of OSV-1. This plot was made using TMHMM server v2.0 (http://www.cbs.dtu.dk/services/TMHMM/). WPDV, wobbly possum disease virus (GenBank #JN116253); EAV, equine arteritis virus (NC_002532); APRAV-1, African pouched rat virus 1 (NC_026439.1); LaDV-1/2, lactate dehydrogenase-elevating virus 1 and 2 (NC_001639 and L13298.1); PRRSV-1/2, porcine reproductive and respiratory syndrome viruses 1 and 2 (M96262 and NC_001961); RatAV-1, rat arterivirus 1 (NC028963); DeBMV-1, DeBrazza’s monkey virus 1 (NC_026509); DMVV-1; Drakensberg Mountain vervet virus 1 (NC_029992); KKCBV-1, Kafue kinda-chacma baboon virus 1 (NC029053); KRCV-1/2, Kibale red colobus viruses 1 and 2 (HQ845737 and KC787631.1); KRTGV-1/2, Kibale red-tailed guenon viruses 1 and 2 (JX473849 and JX473847); MYBV-1, Mikumi yellow baboon virus 1 (NC_025112.1); PBJV, Pebjah virus (KR139838); SHEV, simian hemorrhagic encephalitis virus (KM677927); SHFV, simian hemorrhagic fever virus (NC_003092); SWBV-1, Southwest baboon virus 1 (NC_025113.1); ZMbV-1, Zambian malbrouck virus 1 (KT166441); OSV-1, Olivier’s shrew virus 1 (MF324848). Four additional murid porarteviruses that have not yet been described are identified by GenBank accession numbers only.
Date
Source Vanmechelen, B., Vergote, V., Laenen, L. et al. Expanding the Arterivirus Host Spectrum: Olivier’s Shrew Virus 1, A Novel Arterivirus Discovered in African Giant Shrews. Sci Rep 8, 11171 (2018). https://doi.org/10.1038/s41598-018-29560-x
Author Bert Vanmechelen, Valentijn Vergote, Lies Laenen, Fara Raymond Koundouno, Joseph Akoi Bore, Jiro Wada, Jens H. Kuhn, Miles W. Carroll, and Piet Maes

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