Commons:Featured picture candidates/File:Regulation of gene expression.svg

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File:Regulation of gene expression.svg, featured[edit]

Voting period is over. Please don't add any new votes.Voting period ends on 27 Jul 2016 at 21:28:25 (UTC)
Visit the nomination page to add or modify image notes.

Regulation of gene expression
  • Category: Commons:Featured pictures/Non-photographic media/Computer-generated
  •  Info created by, uploaded by and nominated by Ali Zifan. It also passed under the W3C validator without any errors and warnings. Ali Zifan 21:28, 18 July 2016 (UTC)[reply]
  •  Support -- Ali Zifan 21:28, 18 July 2016 (UTC)[reply]
  •  Oppose I think it's oversimplification. Getting through the membrane isn't that simple and protein hormones (like insulin) just connect to membrane proteins, that then pass on the signal with a cascadal process via mediator molecules. Ok, steroid hormones do enter the cell (not that there is any reference that this is the case with this drawing), but just binding to the receptor and then entering to the nucleus without anything happening to the receptor should be rather uncommon (like why should it float in the cytoplasm and then miraculously decide to enter the nucleus if nothing hasn't changed? there should be at least some conformational change in the receptor). And often there are some co-regulators. And then there is amplification, that is totally taken out from the equation in here. P.S: It might be more practical to base your diagram on some specific gene regulation example. You can do the drawing, but I'm not convinced on the scientific backstory. Kruusamägi (talk) 22:40, 18 July 2016 (UTC)[reply]
    • This diagram actually shows regulation of gene expression by steroid hormone receptor. Hormones that are fat soluble (like steroid) are able to pass through the cell membrane directly and produce their effect by binding to receptors inside the cell. So as you mentioned, and I thank you for that, every regulation of genes won't be the same, and this diagram exclusively display gene expression by steroid hormones. Since Steroid hormone receptors directly regulate gene expression, they would enter the nucleus and it doesn't mean that it will be done "miraculously". I also change the description of the file and requested to rename a file to "Regulation of gene expression by steroid hormone receptor". Ali Zifan 01:48, 19 July 2016 (UTC)[reply]
And as I mentioned before, then there are other issues beside the type of hormone depicted. So naturally I'm not going to change my vote (as if it would had been only that, I would just have suggested to add that "steroid" part into it). And with that "miraculously" I meant that ligand binding usually induces a conformational change in a receptor protein (i.e. there is a reason why it enters the nucleus after binding the hormone). I can't see that in your image. There is just this weird dark hole that is filled. And then again, all of this could be told in an image description and not on the image itself, but there isn't much of a description at a moment.
So, I would definitely wish for a better image description, as at a moment there is more text on the diagram, than on the descriptional part of it. And I'm not fully sure about the used terms as well ("extraocular fluid"(?); and I'd prefer "cell membrane"; and why don't you mention the ribosomes). I don't mind the simplified depiction itself, but without a good textual part to back it up, then it just ain't enough. It is still an encyclopedia. Kruusamägi (talk) 21:42, 19 July 2016 (UTC)[reply]
  •  Neutral for now. It is an exellently executed image, with the requisite option for several languages, but even the two paragraphs of bio-speak above gives me a headache... As soon as someone with more knowledge than I assures me that the science behind it is right, I'll change my vote to support. w.carter-Talk 13:07, 19 July 2016 (UTC)[reply]
  •  Support per nominator's explanation above; it sounds good enough for me. However, I do think a better color could be chosen than that strong purple, which I see as kind of distracting. Daniel Case (talk) 16:01, 19 July 2016 (UTC)[reply]
  •  Support per Daniel --Martin Falbisoner (talk) 19:09, 19 July 2016 (UTC)[reply]
  •  Support 😄 ArionEstar 😜 (talk) 01:36, 20 July 2016 (UTC)[reply]
  •  Support INeverCry 19:32, 23 July 2016 (UTC)[reply]
  •  Comment What are you exactly voting for? Just if the image is pretty or not? As an university student in the field of genetic engineering, this image is a clear no go for me due to the inaccuracies it has. And this nominator's explanation just says that yeah, I had no clue that there are also peptide hormones and I have now updated the image description. How does that "sound good enough"? Kruusamägi (talk) 20:31, 23 July 2016 (UTC)[reply]
    • What do you even mean?! if it was wrong and inaccurate I would definitely withdraw with my nomination; I promise! As I said ,and will say again, this diagram just shows the general steps and basic process of gene expression regulation by steroid hormone receptor. It does not mean that it must depict every single thing going on in the process, because that is not the goal. If those steps were critical to show it would definitely be added. You've already give your opposition and thoughts in here and I don't really know why you are insisting to mislead others about it. Ali Zifan 23:35, 23 July 2016 (UTC)[reply]
Ali, do you see now, why I'm so reluctant to support this?
And if you are already making changes, then please change "hormone" to "steroid hormone" and add marking for "ribosomes". Kruusamägi (talk) 23:22, 24 July 2016 (UTC)[reply]
Confirmed results:
Result: 7 support, 1 oppose, 0 neutral → featured. /INeverCry 02:20, 30 July 2016 (UTC)[reply]
This image will be added to the FP gallery: Non-photographic media/Computer-generated
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