File:Wallerian degeneration.jpg

Summary[edit]

From "The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves", BMC Neuroscience 2005, 6:6 doi:10.1186/1471-2202-6-6. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Wallerian degeneration proceeds in anterograde direction along individual axons after cut injury. Confocal composite picture showing seven consecutive lengths (from top to bottom in overview) of the proximodistal course of an individual YFP labelled axon within a distal nerve stump 40 h after transection demonstrating an anterograde progression of axon fragmentation. Note that this axon has fragmented in its proximal end (upper inset) but not in its distal end (lower inset). Axonal fragments are clearly demarcated by fluorescence interruptions (arrows in upper inset). YFP fluorescence has been pseudo-coloured yellow with the applied confocal imaging software (Biorad LaserSharp 2000). Scale bar: 500 μm

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