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English: Figure 1. Multifaceted immune responses induced by a LAIV. A LAIV mimics a natural infection and induces multifaceted immune responses including antibody responses and T cell responses. Antibodies directed to surface antigens, HA, NA, and M2e neutralize the virus and also mediate antibody effector functions, such as ADCC, ADCP, and CDC, to eliminate virus-infected cells. The internal viral proteins are also target antigens for generation of antibodies with effector functions. Whether the effector functions of antibodies directed to the internal proteins have protective roles has not been clearly elucidated yet. In addition, cytotoxic T cells are directed to the internal viral proteins, which mediate the elimination of virus-infected cells via direct contact of cytokine production.