File:Steroidogenesis pl.svg

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Polski: Enzymy biorące udział w steroidogenezie.

Uwagi: W miejscu gdzie stereochemia nie jest wyświetlana, jest taka sama jak dla Cholesterol lub w pokazanej powyżej grupie.

  • HSD: Dehydrogenaza hydroksysteroidu

English: Enzymes, their cellular location, substrates and products in human steroidogenesis.

Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens. However, they partly overlap, e.g. mineralocorticoids and glucocorticoids.

White circles indicate changes in molecular structure compared with precursors. For more information on interpretation of molecular structures, see Wikipedia:structural formula.

HSD: Hydroxysteroid dehydrogenase

References:

  • Boron WF, Boulpaep EL (2003) Medical Physiology: A Cellular And Molecular Approach, Elsevier/Saunders, pp. page 1,300 ISBN: 1-4160-2328-3.
  • For the absence of conversion of corticosterone to cortisol: Steroid hormone biosynthesis Reference pathway (KO). KEGG: Kyoto Encyclopedia of Genes and Genomes. Kyoto University Bioinformatics Center. (1 November 2013).
There is no appreciable conversion of corticosterone to cortisol in the adrenal cortex as 21-OH steroids are poor substrates for 17-alpha hydroxylase.

Further reading:

  • Hanukoglu I (1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology 43 (8): 779–804. DOI:10.1016/0960-0760(92)90307-5. PMID 22217824.
  • Payne AH, Hales DB (2004). "Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones". Endocrine Reviews 25 (6): 947–70. DOI:10.1210/er.2003-0030. PMID 15583024.
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This is a retouched picture, which means that it has been digitally altered from its original version. Modifications: Polish translation. The original can be viewed here: Steroidogenesis.svg: . Modifications made by M1llx.

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Date/TimeThumbnailDimensionsUserComment
current11:34, 16 April 2021Thumbnail for version as of 11:34, 16 April 20211,245 × 1,105 (133 KB)M1llx (talk | contribs)error fix (17α-hydroksypregnenolon used twice)
12:42, 11 March 2019Thumbnail for version as of 12:42, 11 March 20191,245 × 1,105 (133 KB)M1llx (talk | contribs)Minor placement fix.
12:41, 11 March 2019Thumbnail for version as of 12:41, 11 March 20191,245 × 1,105 (133 KB)M1llx (talk | contribs)Minor placement fix
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