File:Signal transduction v1.png
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File:Signal transduction pathways (zh-cn).svg is a vector version of this file. It should be used in place of this PNG file when not inferior.
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DescriptionSignal transduction v1.png | Signal transduction pathways. Picture is a new version of old figure self-made in illustrator. |
Date | 22 March 2007 (original upload date) |
Source |
Originally from {Molecular cell biology. Lodish, Harvey 5 ed: - New York : W. H. Freeman and Co., 2003, 973 s. b ill. ISBN: 0-7167-4366-3. Libris: 8926100. The Hallmarks of Cancer, Douglas Hanahan and Robert A. Weinberg, Cell, Vol. 100, 57–70, January 7, 2000. http://www.weizmann.ac.il/home/fedomany/Bioinfo05/lecture6_Hanahan.pdf |
Author | Roadnottaken at English Wikipedia |
Other versions | Derivative works of this file: Signal transduction pathways (zh-cn).svg |
Involved proteins and Wikipedia links[edit]
--> = stimulation
--| = inhibition
Pathways involved:
en:Growth factors
-->RTK en:Receptor tyrosine kinase
-->en:Grb2, SOS en:Son of Sevenless
-->en:Ras
-->Raf
-->MEK en:MAPK/ERK kinase
-->en:MAPK --> Jun, en:Mad:Max
-->ERK
-->Fos en:C-fos
MEK --> en:MEKK
--> en:Myc:Max
PLC en:phospholipase C
-->PKC en:protein kinase c
-->Raf
en:Ras
-->en:Cdc42
-->en:Rac
-->en:Rho
Mos en:c-Mos
-->MEK en:MAPK/ERK kinase
ECM en:Extracellular matrix
-->en:Integrins
Integrins
-->en:Cdc42
-->en:PI3K
-->en:Rac
-->en:JNK
-->Jun
Integrins
-->en:FAK Src
-->Cas en:CRK-associated substrate
-->en:CRK
Integrins
-->Fyn Shc en:Src homology 2 domain-containing
-->en:Ras
Hormones,
e.g.
en:bombesin
-->en:7TM-receptor
-->G-prot en:G-protein
-->en:Ras, en:PI3K, Ad cycl en:Adenylate cyclase
-->PKA en:protein kinase A
-->en:CREB
e.g.
en:estrogen
-->en:NHR
Survival factors
e.g.
en:IGF1
-->RTK en:Receptor tyrosine kinase
-->en:PI3K
-->PKC en:Protein kinase C
-->en:NF-kB
PI3K
-->en:Akt
-->Akka en:Akk-alpha
-->en:IκB
-->NF-kB
Cytokines
-->Cytokine R en:Cytokine-Receptor
-->en:Jaks
-->Stats
-->Bcl XL
--|en:cytochrome c
Abnormality sensor
e.g.
Bim
-->Mt en:Mitochondria
-->en:cytochrome c
-->casp9 en:caspase 9
-->en:apoptosis
Akt
--|Bad en:Bcl-2-associated death promoter
--> Mt en:Mitochondria
en:Decoy Receptor
--|en:Death factors
e.g.
FasL en:Fas ligand
-->Fas
-->en:FADD
-->en:caspase 8
-->apoptosis
caspase 8
-->en:Bld
-->Mt en:Mitochondria
-->apoptosis
FAP en:Fas-associated phosphatase
--|Fas
Changes in gene expression
-->ARF
--|en:MDM2
--|en:p53
-->Bax
-->Mt en:Mitochondria
-->apoptosis
Antigrowth factors
e.g.
en:TGFβ
-->TGFβR en:TGFβ receptors
-->en:Smads
-->p15, p27]], p21
p15
--|cycl D en:Cyclin D CDK4 en:Cyclin-dependent kinase 4
--|Rb en:Retinoblastoma protein
--|en:E2F
p21
--|cycl E en:Cyclin E CDK2 en:Cyclin-dependent kinase 2
en:HPVE7 --|Rb en:Retinoblastoma protein
Hedgehog
--|Patched
-->en:Smoothened
-->Gil
-->Changes in gene expression
en:Sufu
--> Gil
Wnt
-->en:Frizzled
-->Dishevelled
-->en:GSK-3β
-->APC
-->en:β-catenin
β-catenin + TCF en:T-cell factor
--> Gene expression
Licensing[edit]
Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled GNU Free Documentation License.http://www.gnu.org/copyleft/fdl.htmlGFDLGNU Free Documentation Licensetruetrue |
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license. | ||
Attribution: Roadnottaken | ||
| ||
This licensing tag was added to this file as part of the GFDL licensing update.http://creativecommons.org/licenses/by-sa/3.0/CC BY-SA 3.0Creative Commons Attribution-Share Alike 3.0truetrue |
Original upload log[edit]
(All user names refer to en.wikipedia)
- 2007-03-22 23:24 Roadnottaken 1858×1364×8 (259189 bytes) new version of old figure. self-made in illustrator. contact me for .AI file ~~~~
- 2007-03-22 23:18 Roadnottaken 1858×1364×8 (258214 bytes) fixed error in old figure. self-made in illustrator. (contact me for .AI file) ~~~~
- 2007-03-22 23:14 Roadnottaken 1858×1364×8 (251473 bytes) new version of old figure self-made in illustrator.
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 11:20, 27 May 2007 | 1,858 × 1,364 (253 KB) | Chaos (talk | contribs) | Created by w:User:Roadnottaken , he putted it under GFDL see [http://en.wikipedia.org/wiki/Image:Signal_transduction_v1.png] {{GFDL-user-w|en|En Wikipedia|Roadnottaken}} {{GFDL}} |
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