File:Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers.jpg
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DescriptionSchematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers.jpg |
English: Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers. A) Various membrane resident proteins and lipids like FR-GPI, prions, LRP, uPAR, cholesterol, sphingolipids and cholera-toxin bound to GM1 are present in a diffuse distribution in the plasma membrane. B) GPI-APs like FR-GPI align with cholesterol and sphingolipids to form lateral aggregates termed as rafts. uPAR and prion proteins, although GPI-anchored, interact with LRP and are endocytosed into the clathrin-coated pits. The interaction of the protein domains of uPAR and Prion with LRP seems to override the influence of the lateral segregation into rafts mediated by the GPI-anchor of these proteins. LRP has signal sequences in the cytoplasmic domain for recruitment into clathrin-coated pits. C and D) Raft-included markers like FR-GPI and cholera toxin bound to GM1 are endocytosed into GEECs whereas uPAR:LRP and prion;LRP complexes are endocytosed into vacuoles derived from clathrin-coated pits. Lakhan et al. Journal of Biomedical Science 2009 16:93 doi:10.1186/1423-0127-16-93 |
Date | |
Source | Endocytosis of glycosylphosphatidylinositol-anchored proteins |
Author | Shaheen E Lakhan , Shefali Sabharanjak and Ananya De |
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© 2009 Lakhan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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current | 18:50, 22 October 2009 | 1,007 × 3,563 (523 KB) | CopperKettle (talk | contribs) | {{Information |Description={{en|1=Schematic visualization of endocytic routes adopted by various GPI-Anchored proteins and other endocytic markers. A) Various membrane resident proteins and lipids like FR-GPI, prions, LRP, uPAR, cholesterol, sphingolipids |
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