File:SARS-CoV MERS-CoV genome organization and S-protein domains.png
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DescriptionSARS-CoV MERS-CoV genome organization and S-protein domains.png |
English: Schematic representation of the genome organization and functional domains of S protein for SARS-CoV and MERS-CoV. The single-stranded RNA genomes of SARS-CoV and MERS-CoV encode two large genes, the ORF1a and ORF1b genes, which encode 16 non-structural proteins (nsp1–nsp16) that are highly conserved throughout coronaviruses. The structural genes encode the structural proteins, spike (S), envelope (E), membrane (M), and nucleocapsid (N), which are common features to all coronaviruses. The accessory genes (shades of green) are unique to different coronaviruses in terms of number, genomic organization, sequence, and function. The structure of each S protein is shown beneath the genome organization. The S protein mainly contains the S1 and S2 subunits. The residue numbers in each region represent their positions in the S protein of SARS and MERS, respectively. The S1/S2 cleavage sites are highlighted by dotted lines. SARS-CoV, severe acute respiratory syndrome coronavirus; MERS-CoV, Middle East respiratory syndrome coronavirus; CP, cytoplasm domain; FP, fusion peptide; HR, heptad repeat; RBD, receptor-binding domain; RBM, receptor-binding motif; SP, signal peptide; TM, transmembrane domain.
Русский: Схематическое изображение организации генома и функциональных доменов S-белков вирусов SARS-CoV и MERS-CoV. Одноцепочечные РНК-геномы SARS-CoV и MERS-CoV содержат два больших гена - ORF1a и ORF1b, которые кодируют 16 неструктурных белков (nsp1–nsp16), которые у короронавирусов являются высоко консерватиными. Структурные гены кодируют структурные белки - S (шип), E (оболочка), M (Мембрана) и N (нуклеокапсид), которые являются общими элементами всех коронавирусов. Вспомогательные гены (оттенки зелёного) уникальны для конкретных коронавирусов по своему количеству, организации генома, последовательности и функции. S-белок в основном состоит из из субъединиц S1 и S2. Числа в каждом из участков обозначают их позицию в S-белках соответственно SARS и MERS. Сайты расщепления S1/S2 отмечены пунктирной линией. SARS-CoV - коронавирус тяжёлого острого респираторного синдрома; MERS-CoV - коронавирус ближневосточного респираторного синдрома; CP - цитоплазмический домен; FP - пептид слияния; HR - heptad repeat (участок повторения семи аминокислот); RBD - рецептор-связывающий домен; RBM - рецептор-связывающий мотив; SP - сигнальный пептид; TM - трансмембранный домен. |
Date | |
Source |
https://www.mdpi.com/1999-4915/11/1/59 Song, Zhiqi, Yanfeng Xu, Linlin Bao, Ling Zhang, Pin Yu, Yajin Qu, Hua Zhu, Wenjie Zhao, Yunlin Han, and Chuan Qin. 2019. "From SARS to MERS, Thrusting Coronaviruses into the Spotlight" Viruses 11, no. 1: 59. https://doi.org/10.3390/v11010059 |
Author | Zhiqi Song, Yanfeng Xu, Linlin Bao, Ling Zhang, Pin Yu, Yajin Qu, Hua Zhu, Wenjie Zhao, Yunlin Han and Chuan Qin; |
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Date/Time | Thumbnail | Dimensions | User | Comment | |
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current | 15:19, 21 March 2020 | 1,865 × 1,242 (747 KB) | Drbug (talk | contribs) | Uploaded a work by Zhiqi Song, Yanfeng Xu, Linlin Bao, Ling Zhang, Pin Yu, Yajin Qu, Hua Zhu, Wenjie Zhao, Yunlin Han and Chuan Qin; Fang Li, Lanying Du (Eds.) from https://www.mdpi.com/books/pdfview/book/1893 Zhiqi Song, Yanfeng Xu, Linlin Bao, Ling Zhang, Pin Yu, Yajin Qu, Hua Zhu, Wenjie Zhao, Yunlin Han and Chuan Qin From SARS to MERS, Thrusting Coronaviruses into the Spotlight Received: 16 December 2018; Accepted: 9 January 2019; Published: 14 January 2019 // Fang Li, Lanying Du (Eds.)... |
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- Usage on ar.wikipedia.org
- إشارة تغليف فيروس كورونا
- البروتين الغلافي لفيروس كورونا
- البروتين الغشائي لفيروس كورونا
- البروتين الشوكي لفيروس كورونا
- بروتين القفيصة النووية لفيروس كورونا
- ORF3a
- قالب:جينومات فيروس كورونا
- ORF3b
- ORF3c
- ORF3d
- ORF6
- ORF7a
- ORF7b
- ORF8
- ORF9b
- ORF9c
- ORF10
- منطقة غير مترجمة 5' لفيروس كورونا
- منطقة غير مترجمة 3' لفيروس كورونا
- عقدة كاذبة لمغم 3' لفيروس كورونا
- عنصر تحفيز انزياح الإطار لفيروس كورونا
- نمط مماثل للحلقة الجذعية 2 لمغم 3' لفيروس كورونا
- قالب:تصنيف فيروس كورونا ألفا
- قالب:تصنيف فيروس كورونا بيتا
- بروتياز مماثل لـ3C
- Usage on bn.wikipedia.org
- Usage on en.wikipedia.org
- Coronavirus
- Coronavirus 3′ stem-loop II-like motif (s2m)
- Coronavirus 3′ UTR pseudoknot
- Coronavirus frameshifting stimulation element
- Coronavirus packaging signal
- ORF7a
- 3C-like protease
- Coronavirus 5′ UTR
- Coronavirus 3′ UTR
- ORF3b
- ORF3d
- Template:Coronavirus genomes
- Coronavirus envelope protein
- Coronavirus membrane protein
- Coronavirus nucleocapsid protein
- Coronavirus spike protein
- ORF3c
- ORF3a
- ORF7b
- ORF8
- ORF6
- ORF9b
- ORF9c
- ORF10
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Horizontal resolution | 28.35 dpc |
Vertical resolution | 28.35 dpc |
File change date and time | 14:31, 21 March 2020 |