File:Role of primary cilia in Notch signaling.png
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| Description | Figure 6. Role of primary cilia in Notch signaling. (A) Notch receptor localizes on the primary cilium. Following the binding of the Notch receptor to the ligands DLL/JAG, NICD is cleaved by presenilin (Pres), the catalytic subunit of γ-secretase, which localizes on the basal body. Cleaved NICD translocates to the nucleus. It serves as a transcriptional co-activator of the RBPj (Recombination signal Binding Protein for immunoglobulin kappa j region) to express Notch response genes. (B) In the absence of primary cilia, expression of Notch target genes is halted since Notch receptor cannot localize to the ciliary membrane and be cleaved by presenilin, resulting in defective differentiation. Created with BioRender.com. |
| Date | |
| Source | https://www.mdpi.com/2073-4409/10/6/1428 https://doi.org/10.3390/cells10061428 Cilium Is Involved in Stem Cell Differentiation and Renewal through the Regulation of Multiple Signaling Pathways. Cells 2021, 10, 1428. |
| Author | Yanardag, S.; Pugacheva, E.N. Primary |
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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| current | 13:52, 5 May 2024 | | 3,180 × 2,681 (800 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 6. Role of primary cilia in Notch signaling. (A) Notch receptor localizes on the primary cilium. Following the binding of the Notch receptor to the ligands DLL/JAG, NICD is cleaved by presenilin (Pres), the catalytic subunit of γ-secretase, which localizes on the basal body. Cleaved NICD translocates to the nucleus. It serves as a transcriptional co-activator of the RBPj (Recombination signal Binding Protein for immunoglobulin kappa j region) to express Notch... |
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