File:Remdesivir molecule.png
Remdesivir_molecule.png (456 × 393 pixels, file size: 718 KB, MIME type: image/png)
Captions
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Summary[edit]
| Description |
3D molecular structure (Jmol) of remdesivir (RDV) showing electrostatic potential surfaces (range -0.1 0.1). RDV is an antiviral compound with a broad spectrum of antiviral activities (e.g. SARS-CoV and MERS-CoV) and currently being used in clinical trials against the novel coronavirus COVID-19 to test its clinical efficiacy. Chemical formula C27H35N6O8P. Legend: carbon atom grey; hydrogen, white; nitrogen, blue; oxygen, red; phosphorous, yellow. IUPAC name (2S)-2-{(2R,3S,4R,5R)-[5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester. The molecule contains several aromatic rings with delocalized π bonding. RDV is a prodrug which is metabolized to the nucleoside analog GS-5734 that targets viral RNA polymerase. An effective nucleoside analog must evade proofreading (by 3′-5′ exoribonuclease) to successfully interfere with CoV RNA synthesis for better clinical efficiacy. |
| Date | |
| Source | Remdesivir molecule |
| Author | ChiralJon |
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This image was originally posted to Flickr by ChiralJon at https://flickr.com/photos/69057297@N04/49624624486 (archive). It was reviewed on 7 March 2020 by FlickreviewR 2 and was confirmed to be licensed under the terms of the cc-by-2.0. |
File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 08:28, 13 March 2020 | | 456 × 393 (718 KB) | GlobalPhotos1 (talk | contribs) | Revised molecule stereochemistry and change to overall electrostatic potential. |
| 12:24, 7 March 2020 |  | 460 × 421 (586 KB) | GlobalPhotos1 (talk | contribs) | Transferred from Flickr via #flickr2commons |
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