File:Relevant molecular pathways and targeted agents in TNBC.jpg
Jump to navigation
Jump to search
Size of this preview: 513 × 599 pixels. Other resolutions: 205 × 240 pixels | 411 × 480 pixels | 728 × 850 pixels.
Original file (728 × 850 pixels, file size: 138 KB, MIME type: image/jpeg)
Captions
Captions
Schematic of the most relevant molecular pathways and targeted agents in TNBC.
Summary[edit]
| Description |
English: Schematic of the most relevant molecular pathways and targeted agents in TNBC. Tyrosine kinase receptor is activated upon binding of growth factors leading to activation of signaling pathways. PI3K/AKT pathway and inhibitor drugs: Phosphorylated PI3K activate AKT. The activation of AKT triggers downstream protein complexes mTORC activation that initiate gene transcription and promote cell growth. AR pathway is activated in LAR subtype tumors. Platinum drugs act through DNA damaging mechanism. PARP inhibitors induce “synthetic lethality” in BRCA deficient tumors. |
| Date | |
| Source | https://www.mdpi.com/2072-6694/12/4/916 |
| Author | Elena Vagia,Devalingam Mahalingam andMassimo Cristofanilli |
Licensing[edit]
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 12:00, 18 March 2022 | | 728 × 850 (138 KB) | Andrawaag (talk | contribs) | Uploaded a work by Elena Vagia,Devalingam Mahalingam andMassimo Cristofanilli from https://www.mdpi.com/2072-6694/12/4/916 with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
