File:Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.jpg
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
![File:Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.jpg](https://upload.wikimedia.org/wikipedia/commons/thumb/3/3e/Post-gastrulation_synthetic_embryos_generated_ex_utero_from_mouse_naive_ESCs.jpg/600px-Post-gastrulation_synthetic_embryos_generated_ex_utero_from_mouse_naive_ESCs.jpg?20220922133955)
Size of this preview: 600 × 600 pixels. Other resolutions: 240 × 240 pixels | 480 × 480 pixels | 996 × 996 pixels.
Original file (996 × 996 pixels, file size: 243 KB, MIME type: image/jpeg)
File information
Structured data
Captions
Captions
Graphical abstract of the study
Синтетические эмбрионы после гаструляции
Summary
[edit]DescriptionPost-gastrulation synthetic embryos generated ex utero from mouse naive ESCs.jpg |
English: Abstract of the study: "In vitro cultured stem cells with distinct developmental capacities can contribute to embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian embryos. However, whether cultured stem cells can independently give rise to entire gastrulating embryo-like structures with embryonic and extraembryonic compartments remains unknown. Here, we adapt a recently established platform for prolonged ex utero growth of natural embryos to generate mouse post-gastrulation synthetic whole embryo models (sEmbryos), with both embryonic and extraembryonic compartments, starting solely from naive ESCs. This was achieved by co-aggregating non-transduced ESCs, with naive ESCs transiently expressing Cdx2 or Gata4 to promote their priming toward trophectoderm and primitive endoderm lineages, respectively. sEmbryos adequately accomplish gastrulation, advance through key developmental milestones, and develop organ progenitors within complex extraembryonic compartments similar to E8.5 stage mouse embryos. Our findings highlight the plastic potential of naive pluripotent cells to self-organize and functionally reconstitute and model the entire mammalian embryo beyond gastrulation." |
Date | |
Source | https://www.cell.com/cell/fulltext/S0092-8674(22)00981-3 |
Author | Authors of the study: Shadi Tarazi, Alejandro Aguilera-Castrejon, Carine Joubran, Nadir Ghanem, Shahd Ashouokhi, Francesco Roncato, Emilie Wildschutz, Montaser Haddad, Bernardo Oldak, Elidet Gomez-Cesar, Nir Livnat, Sergey Viukov, Dmitry Lokshtanov, Segev Naveh-Tassa, Max Rose, Suhair Hanna, Calanit Raanan, Ori Brenner, Merav Kedmi, Hadas Keren-Shaul, Tsvee Lapidot, Itay Maza, Noa Novershtern, Jacob H. Hanna |
Licensing
[edit]![w:en:Creative Commons](https://upload.wikimedia.org/wikipedia/commons/thumb/7/79/CC_some_rights_reserved.svg/90px-CC_some_rights_reserved.svg.png)
![attribution](https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Cc-by_new_white.svg/24px-Cc-by_new_white.svg.png)
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 13:39, 22 September 2022 | ![]() | 996 × 996 (243 KB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Shadi Tarazi, Alejandro Aguilera-Castrejon, Carine Joubran, Nadir Ghanem, Shahd Ashouokhi, Francesco Roncato, Emilie Wildschutz, Montaser Haddad, Bernardo Oldak, Elidet Gomez-Cesar, Nir Livnat, Sergey Viukov, Dmitry Lokshtanov, Segev Naveh-Tassa, Max Rose, Suhair Hanna, Calanit Raanan, Ori Brenner, Merav Kedmi, Hadas Keren-Shaul, Tsvee Lapidot, Itay Maza, Noa Novershtern, Jacob H. Hanna from https://www.cell.com/cell/fulltext/S0092-8674(22)00981-3 with... |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on en.wikipedia.org
- Usage on fr.wikipedia.org
- Usage on ru.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
JPEG file comment | HiRes |
---|