File:Pathology in CWD-Infected Animals.jpg

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English: Pathology in CWD-Infected Animals


(A) Histologic lesions of CWD in the dorsal motor nuclei of the vagus nerve within the medulla oblongata of a CWD-affected elk. Note spongiform change, intraneuronal vacuoles, and mild gliosis (hematoxylin and eosin stain, 1003 magnification).
(B) PrP amyloid deposit stained by immunohistochemistry (brown) and surrounded by vacuoles (original magnification 1803).
(C) Perineuronal and extracellular deposits of abnormal PrP (PrPCWD, analogous to PrPSc) in a CWD-affected mule deer (original magnification1803).


(D) PrPCWD deposits in the germinal centres of lymphoid follicles in the tonsils of a mule deer (immunohistochemistry, original magnification 503). PLoS Pathogens DOI:10.1371/journal.ppat.0020026.g002
Français : Anatomo-pathologie de la CWD (ou chronic wasting disease = encéphalopathie spongiforme des cervidés).


(A) coupe histologique de lésions typiques de l'encéphalopathie des cervidés dans le noyau moteur dorsal du nerf vague, dans le bulbe (medulla oblongata) d'un cerf malade. Noter les modifications spongiformes, les vacuoles intraneuronale, et une gliose modérée (coloration à l'hématoxyline et éosine, grossissement 1.003 x).
(B) dépôt amyloïde PrP coloré par immuno-histochimie (brun) et entourées de vacuoles (grossissement 1803 x).
(C) Dépôts Périneuronaux et extracellulaires de prions anormaux (PrPCWD, analogue à la PrPSc) chez un cerf malade de la CWD (Grossissement original de 1803x).


(D) Dépôts de prions dans les centres germinatifs des follicules lymphoïdes dans les amygdales d'un cerf (immunohistochimie, grossissement 503x). PLoS Pathogens
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Source Joel C. Watts, Aru Balachandran, David Westaway. The Expanding Universe of Prion Diseases. PLoS Pathogens DOI:10.1371/journal.ppat.0020026.g002
Author Joel C. Watts, Aru Balachandran, David Westaway
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current14:54, 16 May 2008Thumbnail for version as of 14:54, 16 May 2008699 × 456 (58 KB)Filip em (talk | contribs){{Information |Description=Pathology in CWD-Infected Animals (A) Histologic lesions of CWD in the dorsal motor nuclei of the vagus nerve within the medulla oblongata of a CWD-affected elk. Note spongiform change, intraneuronal vacuoles, and mild gliosis (

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