File:Merkel Cell Carcinoma buttock 45-year-old woman.jpg
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Summary[edit]
DescriptionMerkel Cell Carcinoma buttock 45-year-old woman.jpg |
This large tumor presented as a protuberant mass on the buttock of a 45-year-old woman. Microscopically it showed sheets of undifferentiated cells with high nuclear/cytoplasmic ratio, a high mitotic rate, a occasional inconspicuous nucleoli. Immunostains showed strong dot-like and diffuse cytoplasmic positivity for cytokeratins 20, CAM5.2, and AE1-AE3, as well as granular staining for synaptophysin and chromogranin. There were negative reactions for cytokeratin 7, gross cystic disease fluid protein 15, melan-A, S-100 protein, and thyroid transcription factor 1-alpha. Even though the histologic features and immunostain profile was characteristic of a primary skin tumor, the presentation is atypical. Usually, Merkel cell carcinoma presents on the sun-exposed areas of elderly individuals. Therefore, the pathologist recommended workup for the possibility of another primary site, including lung, female genital tract, salivary gland, and other cutaneous site. |
Date | |
Source | Merkel Cell Carcinoma |
Author | Ed Uthman from Houston, TX, USA |
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This image was originally posted to Flickr by euthman at https://www.flickr.com/photos/78147607@N00/414633167. It was reviewed on 13 April 2008 by FlickreviewR and was confirmed to be licensed under the terms of the cc-by-sa-2.0. |
13 April 2008
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current | 08:04, 9 April 2008 | 3,286 × 2,824 (2.72 MB) | Jacopo Werther (talk | contribs) | {{Information |Description= This large tumor presented as a protuberant mass on the buttock of a 45-year-old woman. Microscopically it showed sheets of undifferentiated cells with high nuclear/cytoplasmic ratio, a high mitotic rate, a occasional inconspic |
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Camera manufacturer | NIKON CORPORATION |
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Camera model | NIKON D2X |
Exposure time | 1/20 sec (0.05) |
F-number | f/7.1 |
ISO speed rating | 100 |
Date and time of data generation | 09:26, 8 March 2007 |
Lens focal length | 50 mm |
Orientation | 0 |
Horizontal resolution | 300 dpi |
Vertical resolution | 300 dpi |
Software used | Ver.1.01 |
File change date and time | 09:26, 8 March 2007 |
Y and C positioning | Co-sited |
Exposure Program | Aperture priority |
Exif version | 2.21 |
Date and time of digitizing | 09:26, 8 March 2007 |
Image compression mode | 4 |
APEX exposure bias | 0.66666666666667 |
Maximum land aperture | 3 APEX (f/2.83) |
Metering mode | Center weighted average |
Light source | Unknown |
Flash | Flash did not fire |
DateTime subseconds | 24 |
DateTimeOriginal subseconds | 24 |
DateTimeDigitized subseconds | 24 |
Color space | Uncalibrated |
Sensing method | One-chip color area sensor |
Custom image processing | Normal process |
Exposure mode | Auto exposure |
White balance | Manual white balance |
Digital zoom ratio | 1 |
Focal length in 35 mm film | 75 mm |
Scene capture type | Standard |
Contrast | Soft |
Saturation | Normal |
Sharpness | Normal |
Subject distance range | Unknown |
Unique image ID | 17ccb4dbab08a8488730e800a70ede06 |