File:Free-Fatty-Acid-Induced-PP2A-Hyperactivity-Selectively-Impairs-Hepatic-Insulin-Action-on-Glucose-pone.0027424.g004.jpg

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English: □ Control; ▪ 0.5 mM Palmitate. The protein level of a PP2A structural subunit (PP2Aα) was upregulated in hepatocytes treated with palmitate (a). Meanwhile, PP2A activity was increased by approximately 30 per cent in insulin-resistant palmitate-treated hepatocytes (b, c). PP2A-activity was estimated by the degree of methylation of the PP2A catalytic subunit (b) or a direct phosphatase activity assay (c). Protein levels were normalized to β–actin. Data are averages of western blot quantifications or PP2A activity measurements +/− std. error of the mean, n = 10. * indicates p<0.05. Representative western blots are shown for a and b.
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Source Image file from Galbo T, Olsen G, Quistorff B, Nishimura E (2011). "Free Fatty Acid-Induced PP2A Hyperactivity Selectively Impairs Hepatic Insulin Action on Glucose Metabolism". PLOS ONE. DOI:10.1371/journal.pone.0027424. PMID 22087313. PMC: 3210172.
Author Galbo T, Olsen G, Quistorff B, Nishimura E
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current22:42, 7 May 2016Thumbnail for version as of 22:42, 7 May 2016426 × 311 (45 KB)Recitation-bot (talk | contribs)Automatic upload of media from: doi:10.1371/journal.pone.0027424

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