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English: Reovirus infectious cycle. Viral attachment to host cell surface glycans results in internalization of reovirus via receptor-mediated endocytosis. Alternatively, infectious subvirion particles (ISVPs) can be formed from proteolysis by extracellular proteases allowing their direct entry into cells via membrane penetration. Once internalized, the virus is transported to early and late endosomes where it undergoes proteolytic disassembly and degradation resulting in the formation of ISVPs and subsequently in the release of transcriptionally active viral core particles into the cytoplasm. Activated RNA-dependent RNA polymerase begins primary transcription within the core particles resulting in the release of primary transcripts that, along with protein products of early translation, form complexes or inclusions where further transcription and translation occur which, in turn, ultimately lead to viral replication and assembly, host cell death, and progeny release.