File:Folic acid metabolism and 5-MTHF transport RUS.png

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Folic acid metabolism and 5-MTHF transport across the choroid plexus epithelium in the brain

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Русский: Рисунок 1 из статьи "Фармакорезистентная эпилепсия у ребенка? Возможная причина: церебральная фолатная недостаточность — состояние, поддающееся терапии" (Mafi et al., Brain Sciences, 2020) Метаболизм фолиевой кислоты и перенос 5-MTHF через сосудистое сплетение в ткани мозга. Красными стрелками обозначены последствия нарушения работы фолатного рецептора альфа. Синими стрелками обозначены последствия назначения фолиниевой кислоты. Сокращения: 5-MTHF – 5-метилентетрагидрофолат; B6 – витамин B6; B12 – витамин B12; DHFR – дигидрофолатредуктаза; FRα – фолатный рецептор альфа; Gly – глицин; GSH – глутатион в восстановленном состоянии; GSSG – глутатион в окисленном состоянии; MS – метионинсинтаза; MTHFD – метилентетрагидрофолатдегидрогеназа; MTHFR – метилентетрагидрофолатредуктаза; MTHFS – метилентетрагидрофолатсинтетаза; PC – фосфатидилхолин; PCFT – протон-сопряженный транспортер фолатов; PI – фосфатидилинозитол; RFC – переносчик восстановленных фолатов; SAH – S-аденозилгомоцистеин; SAM – S-аденозилметионин; Ser – серин; SHMT – серингидроксиметилтрансфераза; SM – сфингомиелин.
Date
Source https://www.mdpi.com/2076-3425/10/11/762/htm
Author Sarah Mafi, Pierre-Antoine Faye, Wikipedia User CopperKettle (translation into Russian)

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