File:Fig-2-Possible-targets-against-FFAs-induced-ED.gif

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English: Fig. 2 Possible targets against FFAs-induced ED. The level of FFAs is elevated in obesity/T2DM which contributes to ED. For a healthy endothelium, a balance in the relative pathways should be maintained. Here, we highlight some targets that may serve as important therapeutic avenue against FFAs-induced ED. These targets include Irisin and Exendin-4, which can increase eNOS activity by several means, but their role in ED, specifically induced by FFAs, should be studied. The Nrf2/HO-1 axis, which is a modulator of oxidative stress, might also have great impact to overcome FFAs-induced ED
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Source Arijit Ghosh et. al. "Role of free fatty acids in endothelial dysfunction", Journal of Biomedical Science doi:10.1186/s12929-017-0357-5
Author Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M. Siu, Christopher W. K. Lai
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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( https://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated.

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current11:00, 8 November 2018Thumbnail for version as of 11:00, 8 November 2018472 × 443 (84 KB)Sohmen (talk | contribs)Uploaded by the NOA Upload Tool

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