File:FMRI Dynamic Resting-State Functional Connectivity effects of DMT.jpg

English: "Dynamics changes in brain RSFC under DMT. (A, Left) Areas showing a significant association between real-time intensity ratings and dynamic global functional connectivity (GFC) for DMT minus placebo (P < 0.05, FDR corrected). (A, Middle) Dynamic effects of DMT versus placebo on network GFC, showing significant increases in GFC for DMN/FP/SAL networks—all associated with the TOP of the brain’s principal functional gradient, as well as the LIM network (*P < 0.05, **P < 0.01, ***P < 0.001; FDR corrected). (A, Right) Pairwise functional connectivity (FC) matrix representing the association between intensity ratings and dynamic functional connectivity (significant links are highlighted in the lower diagonal; FDR corrected). (B) Areas showing a significant association between DMT plasma levels and regional GFC, network GFC, and pairwise FC (FDR corrected). (C, Left) Regional GFC across time for placebo, DMT, and (C, Right) DMT minus placebo, overlayed with reported average intensity ratings (±SEM). Black boxes highlight epochs where changes in network GFC are statistically significant (cluster corrected, P < 0.05). (D) Average (DMT—placebo) pairwise FC matrices for the first seven minutes following DMT/placebo administration. (E) A significant association was found between 5-HT2AR density maps and dynamic GFC (representing beta values of the relationship between GFC and intensity ratings). (Networks: VIS = visual; SM = somatomotor; DAN = dorsal attentional; SAL = ventral attentional/salience; LIM = limbic; FP = frontoparietal; DMN = default mode; SC = subcortical regions; TOP = transmodal association pole)."