File:Estrogen-regulated steps in the metabolisms of prostaglandin J2 and retinoic acid.jpg

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Description Figure legend in originating article (CC-by): "Multiple estrogen-regulated steps in the metabolisms of prostaglandin J2 and retinoic acid are implicated in estrogen-dependent growth of human uterine fibroids. Prostaglandin synthesis pathway was taken from the KEGG pathway database and simplified. Retinoic acid metabolic pathway was compiled based on previous work [51], [29]and [55]. E2 stands for 17 β-estradiol, PGH2 for prostaglandin H2, PGD2 for prostaglandin D2, PGJ2 for prostaglandin J2, RA for retinoic acid, RAR for RA receptor, RXR for retinoid × receptor, PPAR for peroxisome proliferator-activated receptor. Five human and rat ortholog and estrogen-regulated genes (NR4A1, ANXA1, L-PGDS, ALDH1A1 and CRABP2) are in bold font. NR4A1 is nuclear receptor subfamily 4, group A, member 1, which is also called NGFI-B (neuronal growth factor-induced clone B) in rat, Nur77 in mouse and TR3 in human. Its roles in cell proliferation and apoptosis summarized in the figure were largely taken from Cao et al [36] and references therein. ANXA1 stands for annexin A1, L-PGDS for lipocalin-type prostaglandin D2 synthase, ALDH1A1 and ALDH1A2 for aldehyde dehydrogenase 1 family, member A1 and member A2 respectively, CRABP2 for cellular retinoic acid binding protein 2, COX1 and COX2 for cyclooxygenase 1 and 2, eRolDH for epithelial retinal dehydrogenase [63]."
Date Article published 2007-04-02, prepared for Commons 2007-12-20.
Source Wei, Tao; Andrew Geiser, Hui-Rong Qian, Chen Su, Leah Helvering, Nalini Kulkarini, Jianyong Shou, Mathias N'Cho, Henry Bryant, Jude Onyia (2007). "DNA microarray data integration by ortholog gene analysis reveals potential molecular mechanisms of estrogen-dependent growth of human uterine fibroids". BMC Women's Health 7 (1): 5. DOI:10.1186/1472-6874-7-5. ISSN 1472-6874. Retrieved on 2007-12-20.
Author Article authors Tao Wei, Andrew Geiser, Hui-Rong Qian, Chen Su, Leah Helvering, Nalini Kulkarini, Jianyong Shou, Mathias N'Cho, Henry Bryant, Jude Onyia
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current21:05, 20 December 2007Thumbnail for version as of 21:05, 20 December 2007726 × 688 (71 KB)OldakQuill (talk | contribs){{Information |Description=Figure legend in originating article (CC-by): "Multiple estrogen-regulated steps in the metabolisms of prostaglandin J2 and retinoic acid are implicated in estrogen-dependent growth of human uterine fibroids. Prostaglandin synth

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