File:Elina Zúñiga for the National Institutes of Health.jpg
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English: Type I interferon induction and exhaustion upon viral infection
Air date: Wednesday, September 23, 2020, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local Views: Total views: 706 (189 Live, 517 On-demand) Category: Immunology Runtime: 01:12:21 Description: IIG Seminar Dr. Zuniga’s laboratory discovered that, in response to a viral infection, systemic type I interferons (IFN-I) are initially elevated but are subsequently and rapidly silenced despite continuous pathogen replication. They showed that there is an IFN-I refractory (or exhaustion) phase, during which the infected host fails to elevate IFN-I upon secondary unrelated infections, explaining delayed viral control and enhanced susceptibility to opportunistic infections. Dr. Zuniga will present their recent work on the mechanisms underlying the initial IFN-I elevation and its subsequent, rapid, suppression after viral infection. For more information go to https://www.niaid.nih.gov/research/immunology-interest-group NLM Title: Type I interferon induction and exhaustion upon viral infection / Elina Zuniga. Author: Zuniga, Elina. National Institutes of Health (U.S.), Publisher: Abstract: (CIT): Dr. Zuniga's laboratory discovered that, in response to a viral infection, systemic type I interferons (IFN-I) are initially elevated but are subsequently and rapidly silenced despite continuous pathogen replication. They showed that there is an IFN-I refractory (or exhaustion) phase, during which the infected host fails to elevate IFN-I upon secondary unrelated infections, explaining delayed viral control and enhanced susceptibility to opportunistic infections. Dr. Zuniga will present their recent work on the mechanisms underlying the initial IFN-I elevation and its subsequent, rapid, suppression after viral infection. Subjects: Interferon Type I--immunology Virus Diseases--immunology Virus Diseases--virology Publication Types: Lecture Webcast NLM Classification: WC 500 NLM ID: 101772209 CIT Live ID: 38716 Permanent link: https://videocast.nih.gov/watch=38716 |
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| Source | Type I interferon induction and exhaustion upon viral infection at 1:12:18, cropped, brightened |
| Author | National Institutes of Health (U.S.) |
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This image is a work of the National Institutes of Health, part of the United States Department of Health and Human Services, taken or made as part of an employee's official duties. As a work of the U.S. federal government, the image is in the public domain.
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| current | 12:06, 29 July 2021 | | 844 × 801 (136 KB) | GRuban (talk | contribs) | Uploaded a work by National Institutes of Health (U.S.) from [https://videocast.nih.gov/watch=38716 Type I interferon induction and exhaustion upon viral infection] at 1:12:18, cropped, brightened with UploadWizard |
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