File:Cohort symptom presence and intensity for Myalgic Encephalomyelitis-Chronic Fatigue Syndrome.jpg

English: "Cohort clinical characteristics (n = 98). Symptom presence and intensity were determined for 63 variables obtained from the UKMEB symptoms assessment. Responses were recorded on an ordinal 4-point scale, with 0 indicating “absent”, 1 indicating “mild”, 2 indicating “moderate”, and 3 indicating “severe”; gray boxes indicate missing data. Category inclusion was determined by calculating the relative mean ordinal weight/intensity for each variable, with a between-group (severe ME compared to MS as the reference group) fold differentiation ≥1.5 mandated for analytical inclusion. Additionally, Fischer's Exact Test was calculated for severe ME versus MS comparison, with the Benjamini–Hochberg (BH) procedure applied to adjust for multiple comparisons (sig. p < 0.05)." "Symptom feature inclusion was determined by calculating the relative mean ordinal intensity for each variable to provide sufficient detail to rank order (as opposed to a median-derived integer with categorical representation) symptoms, allowing for selective inclusion with a >1.5-fold difference between groups (severe ME compared to MS). Figure 1 summarizes the symptoms into a heatmap showing the top 28 clinical variables (Figure 1). A clear difference was observed when comparing the HC with the ME/CFS and MS patients. An increase in the severity of symptoms was seen when moving from mild to severe ME/CFS patients. The most significant measures as assessed by Fischer's Exact Test were calculated based on the severe ME versus MS comparison, with the Benjamini–Hochberg (BH) procedure applied to adjust for multiple comparisons (*p < 0.05)."