File:Cannabioid agonist WIN acting on pancreatic stellate cell.png
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English: Figure 8. Cannabinoid receptor activation reduces invasiveness.
A significant reduction in the number of invaded cells was seen after treatment with WIN (p = 0.0081; A). A near-complete reversal of the reduced invasiveness was seen when the cells were pre-incubated with AM251 or a combination of AM251 and AM630 (A). This was not found with AM630 alone (A). WIN induced a significant decrease in MMP-2 levels (p = 0.026; B) which was partially reversible by a combination of AM251 and AM630 (B). Actin cytoskeleton staining with phalloidin demonstrated that control PSC showed the normal cellular structure (C&D) but that WIN induced a more round and smaller PSC phenotype (E&F). Original magnification: x 40 (C&E), x 80 (D&F). Nuclear stain: DAPI. White bars: control; black bars: WIN55,212-2±AM251/AM630. Data are shown as mean±SEM. Русский: Агонист каннабиноидных рецепторов снижает характеристики воспаления в панкреатических звездчатых клетках. |
| Date | |
| Source | Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells |
| Author | Christoph W. Michalski1,2#*, Milena Maier2#, Mert Erkan1#, Danguole Sauliunaite1, Frank Bergmann3, Pal Pacher4, Sandor Batkai4, Nathalia A. Giese2, Thomas Giese5, Helmut Friess1, Jörg Kleeff1 |
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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
| Other versions | Derivative works of this file: Pancreatic stellate cell cropped.png |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 18:30, 28 August 2009 | | 2,000 × 2,516 (1.85 MB) | CopperKettle (talk | contribs) | downsize |
| 18:28, 28 August 2009 |  | 4,134 × 5,201 (2.78 MB) | CopperKettle (talk | contribs) | {{Information |Description={{en|1=Figure 5. AM251 induces changes in PSC phenotype. (A) Invasion assays demonstrated a trend toward increased invasiveness induced by AM251. (B) MMP-2 levels were unchanged by antagonist treatment. (C&D) AM251-treated panc |
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