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Daclizumab

DescriptionBiomedicines-07-00018-g002.jpg	English: Known and proposed DAC mechanisms of action. (A) DAC binds to CD25 blocking its association with CD132 and CD122. This prevents trans-presentation of CD25 from mDC to T cells and ultimately results in effector T cell and Treg cell death; (B) As a result of CD25 blockade, serum IL-2 levels are elevated allowing for NK cell activation through the intermediate-affinity receptor, CD132 and CD122, and promoting CD56bright NK cell cytotoxicity and survival. DC-dendritic cell; IL-2-interleukin-2; NK-natural killer. Dotted lines show the sequence of events following IL-2 binding to its receptor.
Date	2019
Source	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480729/
Author	Cohan SL, Lucassen EB, Romba MC, Linch SN

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	Date/Time	Thumbnail	Dimensions	User	Comment
current	17:18, 20 April 2024		695 × 574 (51 KB)	Doc James (talk \| contribs)	Cropped 12 % horizontally, 6 % vertically using CropTool with precise mode.
	21:29, 19 April 2024		794 × 610 (53 KB)	Ozzie10aaaa (talk \| contribs)	Uploaded a work by Cohan SL, Lucassen EB, Romba MC, Linch SN from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480729/ with UploadWizard

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