File:Autophagy.jpg
From Wikimedia Commons, the free media repository
Jump to navigation
Jump to search
Size of this preview: 800 × 600 pixels. Other resolutions: 320 × 240 pixels | 640 × 480 pixels | 960 × 720 pixels.
Original file (960 × 720 pixels, file size: 148 KB, MIME type: image/jpeg)
File information
Structured data
Captions
Summary[edit]
DescriptionAutophagy.jpg |
English: Implication of autophagy deregulation in Parkinson's disease (PD).
There are 3 types of autophagy: macroautophagy, microautophagy and chaperone-mediated autophagy (CMA). Deregulation of both macroautophagy and CMA are implicated in the pathogenesis of PD. CMA is involved in the degradation of soluble wildtype alpha-synuclein, the major constituent of Lewy bodies. Nonetheless, once oligomerized or aggregated, alpha-synuclein is likely degraded by macroautophagy instead of CMA. Interestingly, A53T and A30P mutants of alpha-synuclein are poorly degraded by CMA, but are instead degraded by macroautophagy. Furthermore, the alpha-synuclein mutants inhibit CMA, reducing CMA-mediated degradation of alpha-synuclein and survival factor MEF2D. Concomitant with the inhibition of CMA, overexpression of alpha-synuclein mutants results in a compensatory activation of macroautophagy. Activation of macroautophagy is also evident in cells treated with neurotoxin MPP+, a well-established model for Parkinsonism, or following overexpression of GPR37, another protein that is present in Lewy bodies. Finally, recent studies reveal that macroautophagy also plays a role in the turnover of fragmented mitochondria. These observations highlight the potential involvement of the autophagic pathways in the pathogenesis of PD. Español: Papel de la Autofagia en la enfermedad de Parkinson |
Date | Published september 2009 |
Source | Molecular Brain, Biomed Central |
Author | Cheung and Ip |
Permission (Reusing this file) |
This picture is part of a paper distributed under CC-by 2.0 as stated in the link provided. |
Licensing[edit]
This file is licensed under the Creative Commons Attribution 3.0 Unported license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 12:50, 15 April 2010 | 960 × 720 (148 KB) | Gustavocarra (talk | contribs) | {{Information |Description={{en|1='''Implication of autophagy deregulation in Parkinson's disease (PD).'''<br/> There are 3 types of autophagy: macroautophagy, microautophagy and chaperone-mediated autophagy (CMA). Deregulation of both macroautophagy and |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on cs.wikipedia.org
- Usage on en.wikipedia.org
- Usage on he.wikipedia.org
- Usage on ja.wikipedia.org
- Usage on ru.wikibooks.org
- Usage on te.wikipedia.org
- Usage on zh.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
_error | 0 |
---|