File:Amination Kinetics.png

English: a) According to the proposed mechanism for the palladium-catalyzed amination of aryl halides, an induction period will be present as the active catalyst is generated from an inactive pre-catalyst (where L=BINAP). b) This induction period may be observed at early conversion points, before the catalyzed reaction reaches its maximum rate. In same-excess experiments, this will manifest itself in the non-overlying portions of curves designed to intercept the original reaction at intermediate conversion points. Here, a same excess (e=0.60 M) of [ArX] relative to [HNR2] and [MOR] is utilized for each of the curves. The data for these plots were generated from kinetic simulations with CopasiIU with arbitrary rate constants inspired by the mechanism proposed by Shekhar et al. J. Am. Chem. Soc. 2006, 128, 3584.