File:1r4o.png
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Summary[edit]
| Description |
English: Interaction of The Glucocorticoid Receptor with DNA  |
| Date | 24 July 2007 (original upload date) |
| Source |
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| Author | Boghog at en.wikipedia |
Two crystal structures of the glucocorticoid receptor DNA-binding domain complexed with DNA are reported. The domain has a globular fold which contains two Zn-nucleated substructures of distinct conformation and function. When it binds DNA, the domain dimerizes, placing the subunits in adjacent major grooves. In one complex, the DNA has the symmetrical consensus target sequence; in the second, the central spacing between the target's half-sites is larger by one base pair. This results in one subunit interacting specifically with the consensus target half-site and the other nonspecifically with a noncognate element. The DNA-induced dimer fixes the separation of the subunits' recognition surfaces so that the spacing between the half-sites becomes a critical feature of the target sequence's identity. Reference Crystallographic Analysis of the Interaction of The Glucocorticoid Receptor with DNA Luisi, B.F., Xu, W.X., Otwinowski, Z., Freedman, L.P., Yamamoto, K.R., Sigler, P.B. (1991) Nature 352: 497-505
PubMed: 1865905 Search on PubMed DOI: https://doi.org/10.1038/352497a0 Primary Citation of Related Structures: 1GLU, 1R4O, 1R4R
Licensing[edit]
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This work has been released into the public domain by its author, Boghog at English Wikipedia. This applies worldwide. In some countries this may not be legally possible; if so: Boghog grants anyone the right to use this work for any purpose, without any conditions, unless such conditions are required by law. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 08:33, 5 November 2011 | | 960 × 720 (257 KB) | Smaug the Golden (talk | contribs) | New version |
| 18:33, 1 August 2011 |  | 960 × 720 (259 KB) | OgreBot (talk | contribs) | (BOT): Reverting to most recent version; originally uploaded at en.wikipedia on 2007-09-07 05:27:41 by Boghog | |
| 18:33, 1 August 2011 |  | 960 × 720 (189 KB) | OgreBot (talk | contribs) | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2007-07-24 19:18:07 by Boghog | |
| 12:02, 1 August 2011 |  | 960 × 720 (259 KB) | SreeBot (talk | contribs) |
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