File:CRISPR immuunsuse erinevad tüübid.png
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DescriptionCRISPR immuunsuse erinevad tüübid.png |
Eesti: CRISPR immunsuse kolm tüüpi.
Cas1 ja Cas2 valgud tunnevad protospeisseite abil ära rakku tunginud võõr-DNA (1). Protospeisser ligeeritakse kordusjärjestusele, mis asuvad põhijärjestuse kõrval (2). Üheahelaline pikendamine parandab CRISPR järjestuse ja duplitseerib kordusjärjestust. crRNA protsessimise ning interferentsi staadiumites esinevad erinevused, mis jagab CRISPR süsteemid kolmeks (3). Cas geenid lõikavad esmast CRISPR transkripti, mille tulemusena saadakse crRNA-d (4). I tüüpi süsteemis lõikavad Cas6e/Cas6f valgud ssRNA ja dsRNA molekule, mis moodustavad juuksenõela struktuure. II tüüpi süsteemis kasutatakse dsRNA moodustamiseks tracrRNA-d; lõikamine toimub Cas9 ja RNaasIII abil. Tüüp III süsteemis kasutatakse Cas6 homoloogi, mis ei vaja lõikamiseks juuksenõela struktuuri olemasolu (5). II ja III tüüpi süsteemides lõigatakse molekule lisaks veel kas 5´ või 3´ otsest, mille tulemusena saadakse küps crRNA (6). Saadud crRNA-d seonduvad Cas valguga, moodustuvad interferentsi kompleksid (7). Tüüp I ja II süsteemides on valgu ja PAM järjestuse interaktsioon kriitilise tähtsusega võõr-DNA lagundamiseks. Tüüp III süsteemis pole seesugune interaktsioon vajalik (8). |
Date | |
Source | https://en.wikipedia.org/wiki/CRISPR#/media/File:The_Stages_of_CRISPR_immunity.svg |
Author | CtSkennerton |
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6 November 2014
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